Objective To explore whether the Dll4/Notch1 pathway plays a key role in regulating the
vascular endothelial growth factor (VEGF)/VEGF receptor 2 (VEGFR2) driven decidual
angiogenesis and related pregnancy through induction of a tip/stalk phenotype. Methods
Progesterone-replaced ovariectomized pregnant mice received a single injection of
YW152F (Dll4 blocking antibody, BAb) or placebo at embryonic day (E) 4.5. Animals were
sacrificed at different time points; blood and uterus were collected for further analysis …