Novel object recognition test for the investigation of learning and memory in mice
LM Lueptow - JoVE (Journal of Visualized Experiments), 2017 - jove.com
The object recognition test (ORT) is a commonly used behavioral assay for the investigation
of various aspects of learning and memory in mice. The ORT is fairly simple and can be
completed over 3 days: habituation day, training day, and testing day. During training, the
mouse is allowed to explore 2 identical objects. On test day, one of the training objects is
replaced with a novel object. Because mice have an innate preference for novelty, if the
mouse recognizes the familiar object, it will spend most of its time at the novel object. Due to …
of various aspects of learning and memory in mice. The ORT is fairly simple and can be
completed over 3 days: habituation day, training day, and testing day. During training, the
mouse is allowed to explore 2 identical objects. On test day, one of the training objects is
replaced with a novel object. Because mice have an innate preference for novelty, if the
mouse recognizes the familiar object, it will spend most of its time at the novel object. Due to …
